Katalin Karikó’s Breakthrough: How She Modified mRNA to Evade Cellular Rejection

Katalin Karikó made a crucial modification to mRNA to prevent it from being rejected by cells. She replaced one of the nucleosides, uridine, with a synthetic alternative called pseudouridine. This adjustment reduced the inflammatory response and made the mRNA more stable and less likely to trigger the immune system's defense mechanisms.

https://youtube.com/shorts/Q4cnuqePlAY

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